The detectability of the pretreatment EGFR T790M mutations in lung adenocarcinoma using CAST-PCR and digital PCR

• DOI: 10.21037/jtd.2017.07.02
• Publication Date: 2017-08-28T11:08:08Z
• Authors: Tsutomu Tatematsu; Katsuhiro Okuda; Ayumi Suzuki; Risa Oda; Tadashi Sakane; Osamu Kawano; Hiroshi Haneda; Satoru Moriyama; Hidefumi Sasaki; Ryoichi Nakanishi
• Keywords: T790M; Resistance mutation

Background: A gatekeeper T790M mutation is thought to cause resistance epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment. The detection of a 2nd important for planning the next therapy when patients acquire first line EGFR-TKI.