Pulmonary metastasectomy in uterine malignancies: outcome and prognostic factors

• DOI: 10.21037/jtd.2017.07.46
• Publication Date: 2017-10-13T10:05:40Z
• Authors: Marco Anile; Sara Mantovani; Ylenia Pecoraro; Carolina Carillo; Lorenzo Gherzi; Andreina Pagini; Erino Angelo Rendina; Federico Venuta; Daniele Diso
• Keywords: Gynecologic cancer; Pulmonary metastasis; Survival; Pulmonary and Respiratory Medicine; 03 medical and health sciences; 0302 clinical medicine; 3. Good health

This retrospective study is designed to evaluate factors affecting survival in a population of patients receiving pulmonary metastasectomy after gynecologic cancers.Nineteen patients with isolated lung metastases (one or two) were surgically treated with R0 resection. Four of them underwent lobectomies.Six patients (31.6%) received adjuvant therapy and 11 (58%) experienced recurrences after metastasectomy. Five- and ten-year survival were 40.9% and 31.4%, respectively. Five-year survival in patients receiving adjuvant therapy was 52.4%. At multivariate analysis factors negatively influencing survival were a disease-free interval (DFI) of less than 24 months and recurrence after pulmonary metastasectomy.Pulmonary resection for metastatic gynecologic cancer is feasible and effective; adequate selection of patients is mandatory to achieve satisfactory results and long-term survival.