Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease

• DOI: 10.21037/jtd.2018.10.79
• Publication Date: 2018-11-28T12:31:36Z
• Authors: Jing-Lu Jin; Ye-Xuan Cao; Li-Guo Wu; Xiang-Dong You; Yuan-Lin Guo; Na-Qiong Wu; Cheng-Gang Zhu; Ying Gao; Qiu-Ting Dong; Hui-Wen Zhang; Di Sun; Geng Liu; Qian Dong; Jian-Jun Li
• Keywords: Quartile

Triglyceride glucose (TyG) index is a novel marker for metabolic disorders and recently it has been reported to be associated with cardiovascular disease (CVD) risk in apparently healthy individuals. However, the prognostic value of TyG patients stable coronary artery (CAD) not determined.We conducted nested case-control study among 3,745 CAD. Patients were followed up 11,235 person-years. The events (CVEs) defined as all-cause death, non-fatal myocardial infarction (MI), stroke post-discharge revascularization [percutaneous intervention (PCI) bypass grafting (CABG)]. In total, 290 (7.7%) CVEs 1,450 controls matched according age, gender, previous history PCI or CABG duration follow-up. was calculated formula: ln[fasting triglycerides (mg/dL) × fasting plasma (mg/dL)/2].Multivariable Cox proportional hazards models revealed that positively (hazard ratio: 1.364, 95% confidence interval: 1.100-1.691, P=0.005). Kaplan-Meier analysis indicated within highest quartile presented lowest event-free survival (P=0.029). Moreover, 1-standard deviation (SD) increment 23.2% [hazard ratio (HR): 1.232, interval (95% CI): 1.084-1.401] higher CVEs, which superior other triglyceride glycemic related markers.The present study, firstly, showed future suggesting may useful predicting clinical outcomes