Feasibility of autologous fibrin glue in general thoracic surgery

• DOI: 10.21037/jtd.2020.01.01
• Publication Date: 2020-03-23T00:47:17Z
• Authors: Mitsuaki Kawashima; Tadasu Kohno; Sakashi Fujimori; Naoko Kimura; Souichiro Suzuki; Ryuichi Yoshimura; Shinji Yuhara; Akira Kohno; Makoto Wakatabe; Shigeyoshi Makino
• Keywords: Cardiothoracic surgery; GLUE

Fibrin glue effectively controls air leakage in lung surgery; however, allogenic fibrin cannot eliminate the risks of infection and allergy despite current sterilization methods. Autologous (AFG) could be a good alternative, but is not commonly used worldwide because its limited availability lack evidence. Herein, we report clinical outcomes AFG thoracic surgery.We retrospectively analyzed patients who underwent lobectomies or segmentectomies between November 2016 September 2017 our institution. We two types AFGs. One was partially-autologous (PAFG), components which are largely autologous contains thrombin. The other completely-autologous (CAFG) has no components. PAFG first half study period, after CAFG from March onward. Patients did undergo generation were categorized as non-AFG group. perioperative three groups evaluated.A total 207 surgery, including 118 89 segmentectomies. Among them, 83 received PAFG, 94 CAFG, 30 non-AFG. mean postoperative drainage period within few days each group (PAFG vs. non-AFG: 3.23±3.91 3.16±4.04 3.17±4.16 days, respectively; P=0.405), incidence prolonged an acceptable range 13.3% 12.8% 16.7%, P=0.821).The use clinically feasible for AFGs viable alternative to conventional glues.