Overexpression of COX-2 and clinicopathological features of gastric cancer: a meta-analysis

• DOI: 10.21037/tcr.2020.03.52
• Publication Date: 2020-04-30T08:27:00Z
• Authors: Zhili Hu; Yangzhi Hu; Haiping Jiang
• Keywords: Infiltration (HVAC); Distant metastasis

To evaluate the correlation between COX-2 overexpression and clinicopathological features of gastric cancer, thus providing theoretical basis for anti-COX-2 targeted therapy.The literature about expression cancer was searched in PubMed, Wangfang, VIP, CNKI from inception to September 2019, with "gastric cancer", "COX-2", "cyclooxygenase" as keywords. Stata 15.0 used analyze. Age, gender, differentiation, infiltration depth, lymph node metastasis, tumor size, TNM staging were analyzed by OR (95% CI).Nine studies involving 1,289 patients identified, among which 878 cases existed overexpression. related depth (OR=1.76; 95% CI: 1.01-1.306; P<0.01) metastasis (OR=3.08; 1.64-5.79; P<0.01). While, it not age, differentiation size.COX-2 is valuable predicting could be a predictor poor prognosis cancer. COX-2-targeted therapy can considered one comprehensive treatments