The Relations between Polycyclic Aromatic Hydrocarbons Exposure and 1-OHP Levels as a Biomarker of the Exposure

• DOI: 10.21101/cejph.a4179
• Publication Date: 2017-01-17T23:52:57Z
• Authors: Zuzana Klöslová; Marek Drímal; Karol Balog; Kvetoslava Koppová; Jarmila Dubajová
• Keywords: Polycyclic aromatic hydrocarbon

Background and Aim: Polycyclic aromatic hydrocarbons (PAHs) are the products of incomplete combustion or pyrolysis various organic materials. Their ubiquity in environment leads to measurable levels exposure. However, exposure varies strongly between different regions Europe. Some PAHs with four more rings suspected be human carcinogens. Therefore, occupational and/or environmental may cause a significant health risk. The aim study was evaluate current PAH defined groups workers.Methods: industrial sites selected this survey involved originating from coal tar pitch, carbon black, bitumen, rubber fumes. Based on historical data, were expected exhibit quantifiable PAHs. total population consisted 139 persons: 108 workers (85 males 23 females) occupationally exposed aluminium production, production graphite electrodes, road construction, forming industry 31 control individuals two groups.Results: highest concentrations - 8-hour time-weighted average (TWA) (sum 16 components according EPA list), as expected, found plant (55.15 µg.m-3) electrodes (54.25 µg.m-3). lowest personal air samples construction (1.93 1-hydroxypyrene pyrene metabolite (1-OHP) urine group 0.74 µmol.mol-1 creatinine before 2.27 after (arithmetic mean values). 1-OHP post-shift highly correlated airborne air. correlation coefficients (rS) concentration 0.710 0.752 (p < 0.05). This statistical analysis confirmed effect body burden workers. modifying gender, smoking habits, dietary intake, genetically modified metabolism, use medication toxicokinetics not determined significant.Conclusion: results strong an biomarker affirmed.