New treatment strategies in HIV/AIDS infection and the impact of treatment adherence on the quality of life of people living with HIV

• DOI: 10.21101/cejph.a7382
• Publication Date: 2025-04-28T15:48:39Z
• Authors: Dalibor Sedláček; Sam Hofman; Jiří Frei; Marek Malý

The aim of the study was assessment adherence to antiretroviral (ARV) treatment in a population people living with HIV (PWH), improving awareness PWH, drawing attention risk developing drug resistance and subsequent failure. basic cohort consisted PWH followed up long-term at centre University Hospital Pilsen. Adherence assessed by ARV levels. Nucleoside analogs were determined urine high pressure liquid chromatography (HPLC), relation clinical data, viral load (HIV RNA), absolute CD4 CD8 T cell counts. To assess mental physical state patients, modified SF-36 questionnaire used measure social relationships, education ability relax. From group 131 18 (13.7%) zero levels 113 (86.3%) any detectable for 6-12 months. A statistically significant lower demonstrated patients who adhered time test as indicated urine. lymphocyte values adherent were, expected, significantly higher. difference not demonstrated. survey subjective factors influencing degree adherence. consider important: quality care enabling trust, low opportunistic infections, self-sufficiency, sleep, managing leisure activities, good family relationships. Quality life evaluation satisfaction monitored areas similar both groups PWH. Non-adherence leads deterioration may be cause development failure on part patient. or urinary nucleoside repeatedly instructed about need regular sustained medication use. Regular checks laboratory examination service are needed detect early emergence side effects treatment, which initially only laboratory.