Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

• DOI: 10.21203/rs.2.10177/v4
• Publication Date: 2020-01-27T15:52:48Z
• Authors: Paula Whitmire; Cassandra R Ricke...; Andrea Hawkins-Da...; Eduardo Carrasco; Julia Lorence; Gustavo De Leon; Lee Curtin; Spencer Bayless; Kamala Clark-Swanson; Noah Peeri; Christina Corpuz; Christine Paula L...; Bernard Bendok; Luis Gonzalez-Cuyar; Sujay Vora; Maciej M Mrugala; Leland Hu; Lei Wang; Alyx Porter; Priya Kumthekar; Sandra Johnston; Kathleen Egan; Robert Gatenby; Peter Canoll; Joshua Rubin; Kristin Swanson
• Keywords: Female sex

Abstract Background : Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance features has not been thoroughly explored for sex differences. Methods Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have sex-specific impact on survival patients (299 males 195 females). Results Among males, tumor (T1Gd) radius was predictor overall (HR=1.027, p=0.044). females, higher cell net invasion rate detriment to (HR=1.011, p<0.001). Female extreme survivors had significantly smaller tumors (p=0.010 t-test), size correlated with female (p=0.955 CPH). Both male lower proliferation rates than other (M p=0.004, F p=0.001, t-test). Conclusion Despite similar distributions imaging parameters between there difference in how these related outcomes.