Choroidal thickness, ganglion cell complex, and photoreceptor outer segment length evaluation in patients receiving tamoxifen therapy by spectral domain optical coherence tomography

• DOI: 10.21203/rs.2.10351/v2
• Publication Date: 2019-10-12T12:48:14Z
• Authors: selim bolukbasi; Ozge Kandemir Gursel; Akin Cakir; Burak Erden; Gamze Karatas
• Keywords: Outer nuclear layer

Abstract Background To evaluate choroidal thickness, ganglion cell complex (GCC) and photoreceptor outer segment length were measured in patients with breast cancer undergoing tamoxifen therapy, using spectral-domain optical coherence tomography (SD-OCT); results compared those for normal eyes. Methods Forty-four cancer, 41 healthy controls included this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation SD-OCT. Subfoveal, nasal (nasal distance to fovea 500, 1000, 1500 μm), temporal (temporal μm) thickness measurements performed the enhanced depth imaging mode of Using an Early Treatment Diagnostic Retinopathy Study (ETDRS) circle at macular level, automated retinal segmentation software was applied determine GCC. The (PROS) determined manually, as from inner surface ellipsoid zone retina pigment epithelium. Results mean statistically greater group than all quadrants ( p < 0.001 quadrants). Of users (44 eyes 44 patients), 33 (75%) had UCP. Pachychoroid epitheliopathy (PPE) detected five tamoxifen-group (11.3%). Patients PPE one eye UCP fellow eye. Central serous chorioretinopathy findings observed patient. Tamoxifen lower GCC rings ETDRS inlay ring only = 0.027, 0.002, 0.001, 0.030, respectively). No significant difference subfoveal PROS found between groups. Conclusions SD-OCT provides valuable information identifying structural changes evaluating ocular receiving therapy. Increased thinning users. These OCT may be early indicator toxicity therapy follow-up period. Keywords retinopathy, complex, PROS,