Later onset of hypertension increased the risk of dementia in Mild Cognitive Impairment in community

• DOI: 10.21203/rs.2.12902/v1
• Publication Date: 2019-08-28T03:50:28Z
• Authors: hongyun qin; chengping Hu; xudong Zhao; binggen Zhu; Zhicheng Cao; ling Wang; yi Guo
• Keywords: Pulse pressure

Abstract Objective To investigate the effect of later onset hypertension on progression MCI in community. Methods Participants are from The Study (NO.PKJ2010-Y26, 2011), a population-based longitudinal cognition survey people aged 55+, sampled by probability proportional to size cluster. Hypertension age was estimated self-reported information and medical insurance card records, then classified into two groups: middle-age group (onset < 65 years) old-age ≥ years). In order study dementia, incidence dementia compared between groups. Results A total 277 hypertensive mild cognitive impairment (MCI) participants without were followed for 6 years. 56 (20.22%) progressed (MCIp). proportion MCIp (≥ higher than that one (27.0% vs 15.4%; X2 = 5.538, P 0.019). And group, diabetes mellitus those with (24.7% 12.6%; 5.321, 0.021), increased pulse pressure (33.3% 3.902, 0.048). However, multivariate logistic regression analysis showed older only risk (OR=0.732, p=0.029). Conclusions These results suggest that, harmful even cases where level blood maintained at 130/80mmHg antihypertensive management. It is necessary expand research sample improve experimental methods further confirmation.