Increased Th17 and Th22 cell levels predict acute lung injury in patients with sepsis

• DOI: 10.21203/rs.2.15324/v1
• Publication Date: 2019-09-30T02:46:26Z
• Authors: Gang Li; Liangtian Zhang; Nannan Han; Ke Zhang; Hengjie Li
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Abstract Background: Acute lung injury (ALI) is one of the major complications severe sepsis. This study was conducted to investigate levels Th22 and Th17 cells in peripheral blood septic patients with ALI their clinical significance. Results: A total 479 admitted between January 2013 2018 were divided into non-ALI (n = 377) groups 102) based on presence or absence ALI. The cells, interleukin 22 (IL-22), 6 (IL-6) 17 (IL-17) determined. Receiver operating characteristic curve (ROC) analysis performed assess early diagnostic value predict sepsis-induced prediction score (LIPS), IL-6, IL-17, IL-22, Th-22 9.13, 14.02 ng/L, 13.06 22.90 8.80% 7.40%, respectively, significantly higher group than (P < 0.05). Pearson correlation showed that LIPS, significant factors affecting positively correlated IL-22 0.05), LIPS IL-17 0.01). Multivariate logistic regression (OR 1.130), 1.982), =2.612) 2.211) =3.230) independent risk factor for area under 0.844 a cutoff 6.81% sensitivity specificity diagnosis by 78.72% 89.13% which better but statistically similar as compared > Conclusions: are increased induced ALI, may be used diagnose