Blood pressure and risk of cognitive impairment. The role of vascular disease in neurodegeneration.

• DOI: 10.21203/rs.2.18666/v1
• Publication Date: 2019-12-16T20:48:02Z
• Authors: Mar Carmona-Abellan; Malwina Trzeciak; Miriam Recio-Fern...; Beatriz Echeveste; Laura Imaz; Rosario Luquin-Piudo; Mario Riverol
• Keywords: Cognitive Decline

Abstract Background: Both cerebral vascular disorders and cognitive decline increase in incidence with age. The role of disease hemodynamic changes the development deficits is controversial. objective this study was to assess cardiovascular response during cardiac stress testing neurologically asymptomatic individuals who developed impairment several years after testing. Methods: This a retrospective cohort patients underwent between January 2001 December 2010. Patients were followed up until May 2015 we selected those dysfunction including dementia, mild subjective decline, test. Heart rate blood pressure both at rest peak exercise mean R-R interval recorded. For each patient impairment, one matched control did not show by end follow-up period. Results: From 7224 patients, 371 impairment; these, 186 (124 men) met inclusion criteria other as controls. During follow-up, appeared 6.2 ± 4.7 These subsequently had significantly lower at-rest systolic, diastolic than controls (p<0.05). Further, compared controls, their maximum heart higher systolic pressures increased more exercise. Conclusion: results from suggest that differences are present preclinical phase serving potential risk factor for impairment. findings challenge use variability assessment