18F-Flutemetamol PET post-stroke - a seven year follow-up study

• DOI: 10.21203/rs.2.19511/v1
• Publication Date: 2019-12-26T15:09:36Z
• Authors: Guri Hagberg; Hege Ihle-Hansen; Brynjar Fure; Bente Thommessen; Håkon Ihle-Hansen; Anne Rita Øksengård; Mona K. Beyer; Wyller; Ebba Gløersen Müller; Sarah T. Pendlebury; Per Selnes
• Keywords: Stroke; Cognitive Decline; Pittsburgh compound B; Frontal lobe

Abstract Background: Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI unclear. We hypothesize that deposition, measured Flutemetamol ( 18 F-Flut) positron emission tomography (PET), common 7-year survivors diagnosed and, further, quantitatively assessed F-Flut-PET uptake seven years correlates amyloid-β peptide (Aβ₄₂) levels cerebrospinal fluid (CSF) at one year, measures neurodegeneration cognition post-stroke. Methods: 208 patients first-ever or TIA without pre-existing were included during 2007 2008. At one- seven-years post-stroke, cognitive status was assessed, categorized into dementia, mild none. Etiologic sub-classification based on magnetic resonance imaging (MRI) findings, CSF biomarkers clinical profile. years, offered F-Flut-PET, amyloid-positivity visually semi-quantitatively. associations between standardized value ratios (SUVr) (medial temporal lobe atrophy (MTLA), global cortical (GCA)) (Mini-Mental State Exam (MMSE), Trail-making test A (TMT-A)) Aβ₄₂ using linear regression. Results: In all, 111 completed follow-up, 26 agreed to PET imaging, whom 13 had from year. Thirteen out but only positivity. MTA grade, GCA scale, MMSE score TMT-A did not correlate SUVr this cohort.Conclusions: Amyloid binding CI. Quantitatively other related cognition. Therefore may be a key mediator