ImPROving TB outcomes by modifying LIFE-style behaviours through a brief motivational intervention followed by short text messages (ProLife): study protocol for a randomised controlled trial

• DOI: 10.21203/rs.2.480/v1
• Publication Date: 2019-03-22T11:52:47Z
• Authors: Andrew Stephen Mo...; Goedele Maria Lou...; Noreen Dadirai Md; Neo Marojele; John Tumbo; Olufemi Babatunde...; Max Oscar Bachmann; Mona Kanaan; Astrid Turner; Steve Parrott; Kamran Siddiqi; Olalekan Abdulwah...
• Keywords: Motivational Interviewing; Brief intervention

Abstract Background South Africa is among the 7 highest tuberculosis (TB) burden countries. Harmful lifestyle behaviours, such as smoking and alcohol, poor medication adherence can affect clinical outcomes. Modification of these behaviours likely to improve TB treatment outcomes has proven possible using motivational interviewing (MI) techniques or use short message service (SMS) text messaging. There have been no studies assessing effect combined MI SMS interventions on multiple factors Methods This a prospective, multi-centre, two-arm individual randomised controlled trial looking at effectiveness cost-effectiveness complex behavioural intervention (the ProLife programme) improving lifestyle-related in 3 provinces Africa. The programme consists an counselling strategy, delivered by lay health workers, augmented with subsequent SMS. We aim recruit 696 adult participants (aged 18 years over) drug-sensitive pulmonary who are current smokers and/or report harmful hazardous alcohol use. Patients will be consecutively enrolled 27 clinics different districts Participants individually arm receive sessions 1 month apart. Each session followed twice-weekly messages targeting adherence, tobacco smoking, appropriate. assess success, standard World Health Organization (WHO) outcome definitions (primary outcome), well range secondary including cessation, reduction anti-retroviral therapy adherence. Secondary measured 6 months follow-up. Discussion aligns WHO agenda integrating care for chronic diseases life-style, provision cessation treatments, digital technologies. If found effective cost-effective, could significant implications globally successfully implemented wide settings.