Integrated molecular portraits of breast cancer

• DOI: 10.21203/rs.3.pex-2435/v2
• Publication Date: 2024-01-26T16:07:01Z
• Authors: Yi-Zhou Jiang; Ding Ma; Xi Jin; Yi Xiao; Ying Yu; Jinxiu Shi; Yi-Fan Zhou; Tong Fu; Cai-Jin Lin; Lei-Jie Dai; Cheng-Lin Liu; Shen Zhao; Guan-Hua Su; Wanwan Hou; Yaqing Liu; Qingwang Chen; Jingcheng Yang; Naixin Zhang; Wen-Juan Zhang; Wei Liu; Weigang Ge; Wen-Tao Yang; Chao You; Yajia Gu; Virginia Kaklamani; François Bertucci; Claire Verschraegen; Anneleen Daemen; Nakul M. Shah; Ting Wang; Tiannan Guo; Leming Shi; Charles M. Perou; Yuanting Zheng; Wei Huang; Zhi-Ming Shao

Abstract The associated article reports multiomic analysis of breast cancers, where we provided a unique public resource that contributes novel insights into the breast cancer, holding promise for further precision treatment approaches. This protocol not only delineates detailed experimental procedures for sample preparation and data generation but also comprehensive analysis methods for genomics, transcriptomics, proteomics, and metabolomics from breast cancer samples. Furthermore, regarding radiomics and pathomics, the protocol describes the extraction of both radiological and pathological features in detail.