Gamma Knife Radiosurgery Versus Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: a Propensity Score Matching Study

• DOI: 10.21203/rs.3.rs-1193272/v1
• Publication Date: 2022-01-03T23:30:04Z
• Authors: Ke Su; Tao Gu; Ke Xu; Jing Wang; Hongfei Liao; Xueting Li; Lianbin Wen; Yanqiong Song; Jiaqi Zhong; Bingsheng He; Xin Liu; Jie He; Yanlin Liu; Qi Li; Xunjie Feng; Siyu Chen; Binbin Yang; Weihong Huang; Hongping Jin; Xiaotong Luo; Teng Hu; Jiali Chen; Zhenying Wu; Simin Lu; Jianwen Zhang; Mingyue Rao; Yunchuan Xie; Jing Wang; Xiaoning Zhu; Lan Chen; Bo Li; Song Su; Xiaoli Yang; Juan Wang; Hao Zeng; Pan Wang; Min Yan; Xiaojing Chen; Kun He; Yunwei Han
• Keywords: Transcatheter arterial chemoembolization; Subgroup analysis; Liver Cancer

Abstract Background The optimal management for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) is unclear. This study aimed to investigate the efficacy of Gamma knife radiosurgery (GKR) versus transcatheter arterial chemoembolization (TACE) in HCC PVTT. Methods retrospective included 572 PVTT (GKR, 207; TACE, 365). Propensity score matching (PSM) analysis identified 188 matched pairs patients. primary endpoint was overall survival (OS). Results Before PSM, GKR group demonstrated significantly median OS (mOS) than TACE (17.4 vs. 8.0 months, p < 0.001). In subgroup analysis, associated longer II-IV (17.5 8.2 0.001; 19.3 7.4 14.5 6.6 = 0.008, respectively) and comparable I. After had also a (15.8 9.8 superior mOS (all P 0.05) Conclusions better PVTT, especially II-IV.