Electrochemically-Selective Electrode for Quantification of Dorzolamide in Bulk Drug Substance and Dosage Form

• DOI: 10.21203/rs.3.rs-2600528/v1
• Publication Date: 2023-02-23T15:51:29Z
• Authors: Mai M. Mora; Nahla S. Ismail; Hala E. Zaazaa; Shereen A. Boltia
• Keywords: Dorzolamide; Carbon paste electrode; Carbon fibers

Abstract Three smart carbon paste electrodes were fabricated to quantify the dorzolamide hydrochloride DRZ, including conventional I, modified embedding Silica II, and β-cyclodextrin III. This study is built on inserting of DRZ with phosphomolybdic acid create an electroactive moiety dorzolamide-phosphomolybdate ion exchanger using a solvent mediator dibutylphthalate. The three constructed displayed Nernstian responses linear concentration ranges lower detection limits. vital performance created was verified in relation various parameters. enhance selective determination presence inorganic ions, co-formulated drug dosage form timolol maleate excipient benzalkonium chloride. electrode inclusion utilized detect ophthalmic eye drop utilizing direct calibration curve potentiometric titration methods. Satisfactory findings achieved by comparing other reported