Effects of robotic-assisted early mobilization versus conventional mobilization in intensive care unit patients: The MobiStaR trial

• DOI: 10.21203/rs.3.rs-3695698/v1
• Publication Date: 2023-12-08T20:36:32Z
• Authors: Lucas Huebner; Angelika Warmbein; Christina Scharf; Ines Schroeder; Kirsi Manz; Ivanka Rathgeber; Marcus Gutmann; Johanna Biebl; Amrei Mehler-Klamt; Jana Huber; Inge Eberl; Eduard Kraft; Uli Fischer; Michael Zoller
• Keywords: Mobilization

Abstract Background Approximately one in three survivors of critical illness suffers from intensive-care-unit-acquired weakness (ICUAW), which increases mortality and impairs quality life. By specifically counteracting the known risk factors immobilization, active mobilization may mitigate ICUAW its negative effects on patients’ outcomes. In this single-center trial, effect robotic-assisted early intensive care unit (ICU) outcomes was investigated. Methods We enrolled 16 adults scheduled for lung transplantation to receive 20 minutes verticalization twice daily during their first week ICU if deemed feasible by treating team (intervention group: IG). A control group (CG) 13 conventionally mobilized patients after recruited retrospectively. Outcome measures included duration mechanical ventilation, length stay, muscle parameters evaluated ultrasound, life months. Statistical analysis performed using Kaplan–Meier method linear mixed models. Results During ICU, intervention received a mean 5.6 (standard deviation ± 2.9) sessions verticalization. There were no statistically significant differences ventilation (IG: median 126 vs. CG: 78 hours), stay 14 8 days), months between IG CG. Conclusion study, successfully implemented setting. No observed conventional mobilization, new option ICU. However, randomized larger studies are necessary validate adequacy robotic other cohorts. Trial registration This interventional trial registered clinicaltrials.gov as NCT05071248 27/08/2021.