Ultrastructural analysis of cardiomyocytes shows that loss of left ventricular desmosomes leads to shortening of ST segment time in patients with arrhythmogenic cardiomyopathy

• DOI: 10.21203/rs.3.rs-93392/v1
• Publication Date: 2020-10-26T17:43:00Z
• Authors: Yuan Chang; Xiumeng Hua; Yiqing Hu; Wendao Liu; Xiao Chen; Xuexin Fan; Tao. Menghao; Shi Chen; Jiangping Song; Shengshou Hu
• Keywords: Desmosome; Intercalated disc

Abstract Background: Arrhythmogenic cardiomyopathy (AC) is an inherited myocardial disease affecting the both ventricles. It shows large heterogeneity on its clinical, genetic, and pathological manifestations. The intercalated disc remodeling has been investigated in right ventricle (RV) of AC, however, ultrastructural features left (LV) among different genotypes remain unknown. Methods: ultrastructure characters ventricles from 24 AC who fulfilled international Task Force diagnostic 10 normal donor hearts were studied by transmission electron microscope. We applied Pearson correlation analysis to identify relationship between D structure electrocardiogram changes. Results : These patients divided into two subtypes based whether they carried desmosome (D) gene mutation. found that more structures LV than (LV vs. RV, 10.82 ± 3.12% 6.75 1.11%, p=0.001), but density (AC Control, 3.77 1.58 per μm 4.21 1.76 μm, p=0.001) proportion 6.65 2.77% 3.12%, was declined compared with hearts. width 21.38 2.31 nm 18.09 0.98 nm, length 0.17 0.05 0.14 0.01 p=0.002) increased RV Destroyed all patients, regardless carrying a mutation or not. are positively correlated ST segment time patients. mitochondria not Conclusions: patterns had no type mainly showed decrease proportion, manifested as compensatory widening lengthening. loss may cause shortening. From perspective ultrastructure, we concluded output power heart accelerate disintegration.