Inhibitory effect of the NMDA receptor antagonist, dizocilpine (MK-801), on the development of morphine dependence.

• DOI: 10.2131/jts.21.2_135
• Publication Date: 2011-09-20T05:28:19Z
• Authors: Mizue MAKIMURA; Hideya SUGIMOTO; Kazufusa SHINOMIYA; Yozo KABASAWA; Hideomi FUKUDA
• Keywords: Dizocilpine

We investigated the effect of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, (+)-5-methyl-10, 11-dihydro-5H-dibenzo[a, d]cyclohepten-5, 10-iminehydrogen maleate (dizocilpine, MK-801), on hippocampal norepinephrine release in morphine-treated rats order to clarify relationship between NMDA receptors and development morphine dependence. Naloxone hydrochloride injected subcutaneously (s.c.) into morphine-dependent rats, induced an immediate increase release, which was associated with typical withdrawal syndrome. The increased levels persisted for at least 2 hr, even after disappearance behavioral This striking naloxone dependent duration intraberebroventricular (i.c.v.) infusion. Pretreatment dizocilpine before challenge reduced rate rise by rats. Concurrent infusion decreased level challenge. Both pretreatment injection suppressed rearing teeth-chattering signs, but not wet-dog shakes These results suggest that attenuates dependence through receptors, thus interaction opioid may be involved