Biosafety of multiwalled carbon nanotube in mice: a behavioral toxicological approach

• DOI: 10.2131/jts.37.1191
• Publication Date: 2012-11-30T22:55:43Z
• Authors: Saeed Ivani; Isaac Karimi; Seyed Reza Fatemi...
• Keywords: Male; 0303 health sciences; Behavior, Animal; Depression; Nanotubes, Carbon; Reproduction; Mice, Inbred Strains; Organ Size; Thymus Gland; Anxiety; 3. Good health; Mice; 03 medical and health sciences; Drug Delivery Systems; Animals, Newborn; Liver; Pregnancy; Animals; Humans; Female; Injections, Intraperitoneal; Spleen

Multiwalled carbon nanotubes (MWCNTs) with unique chemical and electromechanical properties are ideal candidates for the development of drug delivery platforms. The scarce knowledge effects exposure to MWCNTs during pregnancy on postnatal outcomes motivated us investigate whether intraperitoneal injections (i.p.) mating early affect reproductive neurobehavioral endpoints psychobiological status pups. Thirty virgin female mice were divided three groups (n = 10 each); two treated injected i.p. 1 mg suspended in ml phosphate buffered saline solution (PBS) both day gestation 3, respectively. control group was an equal volume PBS as a vehicle. MWCNT-treated dams did not exhibit considerable changes their performance lactation periods. pups exhibited similar ontogenetic expressions physical compared group. Most notably, increased depressive anxious behaviors parallel adverse effect internal organ weights. absolute thymus weight declined while weights liver spleen decreased by MWCNT Relative almost