Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes

• DOI: 10.2131/jts.37.1275
• Publication Date: 2012-11-30T22:55:43Z
• Authors: Min-Seok Kim; Tsutomu Takahashi; Jin-Yong Lee; Gi-Wook Hwang; Akira Naganuma
• Keywords: Methylmercury

Methylmercury is an environmental pollutant that toxic to the central nervous system; however, molecular mechanisms underlying its toxicity remain unclear. increases expression of several chemokines in cerebellum mice treated with methylmercury. The present study analyzes mechanism methylmercury-induced chemokine using human 1321N1 astrocytes, and shows methylmercury CCL2 these cells. transcription factor NF-κB involved induction expression. increased level p65 subunit nuclei increase was significantly decreased by suppression RNA interference. These results suggest induces through activation astrocytes.