Factors Associated with the Time to Clinical Recovery from Coronavirus Disease 2019 in Pediatric Patients

• DOI: 10.2139/ssrn.3590485
• Publication Date: 2020-06-09T11:31:33Z
• Authors: Aifen Zhou; Hong Xu; Zhixi Liu; Xiaohua Ying; Hua Xu; Xianfeng Wang; Jinmiao Lu; Yidie Huang; Guangfei Wang; Yanling He; Jie Chen; Shuli Ma; Shangrong Zou; Yuxia Cui; Ruijie Chen; Jin Lu; Xuyuan Li; Zhiping Li; Guoying Huang; Weibing Wang
• Keywords: Coronavirus; 2019-20 coronavirus outbreak; Pandemic

Background: The epidemic of disease due to SARS-CoV-2 has caused massive destruction the world economy and overburdened health care systems worldwide. To date, information about epidemiological features potential factors related clinical recovery pediatric COVID-19 patients is lacking.Methods: This retrospective study examined 233 cases confirmed admitted 12 tertiary hospitals in China from January 1, 2020 April 17, 2020. We retrieved electronic medical records these cases, including patient characteristics, laboratory results, information.Findings: median age cohort was 7·50 (IQR: 2·92,12·17) years, 133 (57·1%) were male. Forty-two evaluated as asymptomatic, while 162 25 classified mild or moderate respectively. most common symptoms fever (40·8%), cough (35·6%), nausea (16·3%), coughing productive excess saliva (9·9%). In Cox regression analysis, longer time associated with having SARS-CoV-2-infected family members (HR [95%CI]: 0·56 [0·41–0·79]), comorbidities 0·57 [0·37–0·89]). Regarding types, only severe 0·14 [0·03–0·59]). Interpretation: transmission chain between adult child not one-way, it possible for virus transmit children household setting, vice versa. proportion asymptomatic could be underestimated detection difficulties. Funding Statement: Bill & Melinda Gates Foundation (Grant No. INV-006277).Declaration Interests: authors declare no competing interests.Ethics Approval approved by ethics committee National Children's Medical Center, Hospital Fudan University, followed Declaration Helsinki. Written consent obtained guardians patients.