Association between Early Treatment and Favorable Clinical Outcomes of COVID-19: Evidence from Nine Provinces in China

• DOI: 10.2139/ssrn.3619794
• Publication Date: 2020-07-31T11:41:06Z
• Authors: Nannan Shi; Bin Liu; Ning Liang; Yan Ma; Youwen Ge; Hongmei Wo; Honggang Yi; Heng Gu; Yuan Kuang; Shaowen Tang; Yang Zhao; Lin Tong; Sihong Liu; Chen Zhao; Renbo Chen; Weiguo Bai; Yipin Fan; Zhan Shi; Li Li; Jia Liu; Hao Gu; Yingjie Zhi; Zhifei Wang; Yuanyuan Li; Huizhen Li; Liwen Jiao; Yaxin Tian; Yibai Xiong; Ruili Huo; Jiangfeng Bai; Hong Chen; Liying Chen; Qiao Feng; Tuanmao Guo; Yong Hou; Guifen Hu; Xiaomei Hu; Yunhong Hu; Jin Huang; Qiuhua Huang; Shaozhen Huang; Liang Ji; Haihao Jin; Xiao Lei; Chunyan Li; Guihui Wu; Jike Li; Minqing Li; Quntang Li; Xianyong Li; Hongde Liu; Jinping Liu; Zhang Liu; Yuting Ma; Ya Mao; Liufen Mo; Hui Na; Jingwei Wang; Fangli Song; Sheng Sun; Dongting Wang; Mingxuan Wang; Xiaoyan Wang; Yinzhen Wang; Yudong Wang; Wei Wu; Lanping Wu; Yanhua Xiao; Haijun Xie; Hongming Xu; Shoufang Xu; Ruixia Xue; Chun Yang; Kaijun Yang; Puye Yang; Shengli Yuan; Gongqi Zhang; Jinbo Zhang; Linsong Zhang; Shusen Zhao; Wanying Zhao; Kai Zheng; Yingchun Zhou; Junteng Zhu; Guangxi Li; Tianqing Zhu; Wei Wang; Huamin Zhang; Yanping Wang; Yongyan Wang
• Keywords: Association (psychology); 2019-20 coronavirus outbreak

Background: Few studies have examined the association between treatment given time and clinical outcomes, which is indeed of great importance to management coronavirus disease 2019 (COVID-19). We performed this study explore whether early brings favorable outcomes. Methods: In retrospective multicenter study, we included patients aged 18 87 years with confirmed COVID-19 on admission from 54 hospitals in nine provinces China 21 January 10 March, 2020. Final date follow-up was March 17, All were treated by Lung cleansing & detoxifying decoction combined western medicine. Patients divided into four groups according interval first onset symptoms starting a treatment, i.e., ≤1 week group (≤7 days), 1-2 weeks (>7 days ≤14 2-3 (>14 ≤21 days) >3 (>21 days). Multivariable Cox proportional hazard ratio (HR) models used estimate unadjusted adjusted HRs 95% confidence intervals (CIs) for outcomes (time recovery, viral shedding, duration hospital stay, course disease, fever CT images). Findings: Of 782 (median age 46 old, 405 (52%) male), there 321 (41%) group, 221 (28%) 123 (16%) 117 (15%) group. Compared later (greater than 3 weeks), earlier less 1 week, 2 weeks, or had higher likelihood HR (95% CI) 3.81 (2.65-5.48), 2.63 (1.86-3.73) 1.92 (1.34-2.75), respectively. The median shedding 13 12 <2 respectively, shorter that (P=0.0137). decreased 34 24 days, when every one advance compared (P<0.0001). Treatment within since related decrease 4 terms stay Interpretation: Earlier associated including sooner stay. This paper demonstrated could be an effective strategy epidemic control, can provide evidence government international organizations develop policy COVID-19.Funding Statement: supported "National Science Technology Major Project" (2018ZX10101001-005-003, 2018ZX10101001-005-004).Declaration Interests: authors declare no competing interests.Ethics Approval approved National Administration Traditional Chinese Medicine, Medicine institutional board participating setting. Due urgency COVID-19, requirement informed consent participants replaced verbal consent.