The Tumor Immunological Characterizations of Colon Adenocarcinoma Reveals Distinct Phenotypes with Potential Clinical Impact

• DOI: 10.2139/ssrn.4076827
• Publication Date: 2022-05-27T23:43:47Z
• Authors: Midie Xu; Jinjia Chang; Wenfeng Wang; Xin Wang; Xu Wang; Weiwei Weng; Cong Tan; Meng Zhang; Shujuan Ni; Lei Wang; Zhaohui Huang; Zhenzhong Deng; WenHua Li; Dan Huang; Weiqi Sheng

Accurate immune molecular typing is pivotal for screening out patients with colon adenocarcinoma (COAD) who may benefit from immunotherapy and whose tumor microenvironment (TME) were needed reprogramming to beneficial immune-mediated responses. However, little known about the characteristic of COAD. Here, by calculating enrichment score characteristics in three online COAD datasets (TCGA-COAD, GSE39582 GSE17538), we identified 17 prognostic-related that overlapped at least two datasets. We determined COADs could be stratified into subtypes (IS1-IS3), based on consensus clustering these characteristics. Each ISs associated distinct clinicopathological characteristics, genetic aberrations, tumor-infiltrating cell composition, immunophenotyping (immune 'hot' 'cold'), cytokine profiles, as well different clinical outcomes immunotherapy/therapeutic response. propose subtyping can utilized identify will affected microenvironment. Furthermore, provide a guide personalized cancer prognosis.Funding Information: This work was supported National Natural Science Foundation China (81972249, 81902430,82172702), Clinical Research Project Shanghai Shenkang Hospital Development Center (SHDC2020CR4068), Technology Innovation Municipal (SHDC12020102), (22ZR1413000, 21ZR1414900), technology development fund (19MC1911000), Artificial Intelligence Medical Cooperation Xuhui District (2021-017), (19MC1911000),Shanghai "Rising Stars Talents" Youth Program Talents -Specialist (SHWSRS(2020)_087), Interdisciplinary Jiao Tong University (YG2019QNA40), Key Specialty (shslczdzk01301).Declaration Interests: The authors declared no potential conflicts interest terms research, authorship, and/or publication this article.Ethics Approval Statement: IHC analysis samples approved Ethics Committee FUSCC, all provided informed consent.