Reward Sensitivity Modulates the Brain Reward Pathway in Stress Resilience Via Inherent Neuroendocrine System

• DOI: 10.2139/ssrn.4119461
• Publication Date: 2022-06-11T18:06:07Z
• Authors: Weiyu Hu; Xiaolin Zhao; Yadong Liu; Yipeng Ren; Zhenni Wei; Zihan Tang; Yun Tian; Yadong Sun; Juan Yang
• Keywords: Brain stimulation reward; Resilience; Reward system

Over the last ten years, researchers suggested a critical role for brain reward system in stress resilience. However, no study has provided an empirical link between activity mesostriatal regions during and recovery of cortisol responses. Moreover, although sensitivity as trait been demonstrated to promote resilience, whether it modulates resilience how this effect could be achieved by inherent neuroendocrine remain elusive. To end, seventy young adults participated ScanStress task while their imaging data secretion were collected task. In addition, participants’ sensitivity, awakening response (CAR), brain’s intrinsic functional connectivity also measured. We found left putamen activation exposure positively predicted recovery. was linked with relationship serially mediated CAR right hippocampus (HIP)-left inferior frontal gyrus connectivity. This investigation modulated pathways through interplay diurnal network HIP-prefrontal circuitry. all, current built model highlight dynamic multifaceted interaction pertinent allostasis factors reward-resilience pathway uncovered new sight into function stress.