Chronic Social Instability Stress in Tumor-Bearing and Non-Tumor-Bearing Female Mice: Protective Effects of Reduced IL-10 and Increased CX3CR1 Expression

• DOI: 10.2139/ssrn.4126136
• Publication Date: 2022-06-09T06:56:47Z
• Authors: Alina Díez-Solinska; Andrea Lebeña; Larraitz Garmendia; Ainitze Labaka; Garikoitz Azkona; Joana Perez-Tejada; Oscar Vegas
• Keywords: CX3CR1; Social Stress

Extensive literature has reported a link between stress and tumor progression, both of these factors mental health. Despite the higher incidence affective disorders in females neurochemical differences according to sex, female populations have been understudied. The aim this study was therefore analyze effect on development OF1 mice. For purpose, subjects were inoculated with B16F10 melanoma cells exposed Chronic Social Instability Stress (CSIS) model. Behavioral, neuroendocrine parameters analyzed.Female mice CSIS exhibited reduced body weight increased arousal, but there no evidence depressive behavior or anxiety. Exposure did not affect either corticosterone levels development, although it provoke an imbalance cerebral inflammatory cytokines, decreasing IL-10 expression (IL-6/IL-10 TNF-α/IL-10); chemokines, increasing CX3CR1 (CX3CL1/CX3CR1); glucocorticoid receptors, GR (MR/GR). In contrast, alter and, behavior, so much lesser extent. Tumor inoculation levels, MR/GR ratio hippocampus provoked cytokines differently from stress. These results underscore need for experimental approaches that allow us take sex into account when exploring issue, since appear indicate response is mediated by mechanisms different those often proposed relation male