Beneficial Effects of Low-Intensity Pulsed Ultrasound Therapy on Right Ventricular Dysfunction in Animal Models

• DOI: 10.2139/ssrn.4140851
• Publication Date: 2022-06-21T10:43:08Z
• Authors: Takashi Nakata; Tomohiko Shindo; Kenta Ito; Kumiko Eguchi; Yuto Monma; Sadamitsu Ichijo; Rie Ryoke; Wakako Satoh; Kazunori Kumasaka; Haruka Sato; Ryo Kurosawa; Kimio Satoh; Ryuta Kawashima; Masahito Miura; Hiroshi Kanai; Satoshi Yasuda; Hiroaki Shimokawa
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Right ventricular failure (RVF) is a leading cause of death in patients with pulmonary hypertension; however, effective treatment remains to be developed. We have developed low-intensity pulsed ultrasound therapy for cardiovascular diseases. In this study, we demonstrated that the expression of endothelial nitric oxide synthase (eNOS) in RVF patients was downregulated and that eNOS expression and its downstream pathway were ameliorated through eNOS activation in 2 animal models of RVF. These results indicate that eNOS is an important therapeutic target of RVF, for which low-intensity pulsed ultrasound therapy is a promising therapy for patients with RVF.