Effect of in Utero and Lactational Exposure to a Thyroid Hormone System Disrupting Chemical on Mouse Plasma Metabolome and Brain Transcriptome

• DOI: 10.2139/ssrn.4236041
• Publication Date: 2022-10-04T14:42:29Z
• Authors: Rikke Poulsen; Yanis Zekri; Romain Guyot; Frederic Flamant; Martin Hansen
• Keywords: Metabolome

Highlights● Untargeted transcriptomics and metabolomics are sensitive, unbiased methods to detect toxicity● Maternal hypothyroxinemia due low-dose chemical exposure affects offspring● Compared thyroid hormones, other more sensitive biomarkers were uncovered with omics tools