Elucidating Osseointegration in Vivo in 3d Printed Scaffolds Eliciting Different Foreign Body Responses

• DOI: 10.2139/ssrn.4473618
• Publication Date: 2023-06-24T18:44:35Z
• Authors: Dewei Qiu; Chuanliang Cao; Aruna Prasopthum; Zhenchang Sun; Shan Zhang; Hanwen Yang; Zhiyong Xu; Jun Tao; Fanrong Ai; Jing Yang
• Keywords: 3d printed

A strong bonding (osseointegration) between biomaterial and bone is critical for the clinical success of many orthopaedic dental implants. However, how this interfacial formed in vivo role immune cells process not clear. In study, we investigated bone-material interfaces two different 3D printed porous scaffolds that elicited levels foreign body response (FBR). The polymer/hydroxyapatite composite more intensive FBR evidenced by components (macrophages/foreign giant cells, fibrous tissue) surrounding material surface. Sintered hydroxyapatite showed comparatively less FBR. new appeared to be growing towards rather than osteogenic stem/progenitor first attaching surface followed from material-bone interface immunogenic was heterogenous, coexistence osseointegration components. presence inhibit osseointegration. Where were present there no Our results offer insight on formation interface, which can potentially benefit development better biomaterials future.