A LC-MS/MS Procedure for the Analysis of 19 Perfluoroalkyl Substances (PFASs) in Food Fulfilling Recent EU Regulations Requests

• DOI: 10.2139/ssrn.4496408
• Publication Date: 2023-07-18T21:08:06Z
• Authors: Tommaso Stecconi; Tamara Tavoloni; Arianna Stramenga; Simone Bacchiocchi; Carolina Barola; Alessandra Dubbini; Roberta Galarini; Simone Moretti; Gianni Sagratini; Arianna Piersanti

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are synthetic, stable, fluorinated molecules widely used in consumer products. They non-biodegradable, persistent bio-accumulating. In 2020 European Food Safety Authority (EFSA) lowered the Tolerable Weekly Intake (TWI) for four PFASs (PFOA, PFOS, PFNA, PFHxS) 2022, EU issued a Recommendation asking to monitor twenty-one food. Since 1st January 2023 limits food were set. Here we report sensitive, straightforward robust procedure enabling determination of 19 matrices using liquid chromatography mass spectrometer (LC–MS/MS). Few published methods applicable different covering listed 2022/1431, fulfilling LOQs requested. The method was satisfactory validated (UNI CEI EN ISO/IEC 17025:2018 Regulation (EU) 2022/1428) investigate hen egg samples, highlighting home-produced eggs as more critical farming process PFAS accumulation.