S/Cumgal-41 as an Efficient Hybrid Catalyst for Asymmetric Addition Reaction in Isopropyl Alcohol Solvent

• DOI: 10.2139/ssrn.4530748
• Publication Date: 2023-08-03T18:19:41Z
• Authors: Yitao Gu; Xiaoqian Ren; Zihan Wei; Xiaoming Fu; Tianyi Yang; Chaofei Peng; Linwei Lu; Yiming Ma; Yang Xu; Huimin Zhang; Wenlong Xu; Jinhua Liang
• Keywords: Isopropyl alcohol; Isopropyl

In this study, a series of CuMgAl-LDHs were successfully prepared using coprecipitation method, subsequently, S/CuMgAl-41 was by modifying CuMgAl-41 with thiourea. The physical and chemical properties the catalysts characterized XRD, N2 adsorption-desorption, SEM, ICP, FT-IR, TG-DSC, XPS, then their catalytic performance investigated. results from Hammett titration NH3-TPD analysis indicate that is bifunctional catalyst both acidic alkaline active sites. tests asymmetric synthesis for p-NDB acetone over different in isopropanol solvent obviously show has best effect, because can provide an acid-base of, B acid site, electrostatic effects hydrogen bonding environment after modified thiourea, which conducive to nucleophilic addition reaction stereoselectivity. addition, demonstrate conversion p-NDB, selectivity main prudcts ee value are 76.9%, 81.5% 83.1% under optimal conditions, respectively. Moreover, exhibits excellent reusability stability. What’s more, aldol p-NBD catalyzed S/CuMgAL-41 synergistic result diverse factors such as center on S/CuMgAL-41, bonding, between hydrotalc laminates repulsion. This design method provides new ideas