Biomimetic Crimped/Aligned Microstructure to Optimize the Mechanics of Fibrous Hybrid Materials for Compliant Vascular Grafts

• DOI: 10.2139/ssrn.4534940
• Publication Date: 2023-08-08T13:17:37Z
• Authors: Vince Beachley; Jonathan Kuo; Vladimir Kasyanov; Vladimir Mironov; Xuejun Wen
• Keywords: Bioprosthesis; Tissue Engineering; Tissue Scaffolds; Biomimetics; Biomimetic Materials; Nanofibers; Vascular Grafting; Collagen; Blood Vessel Prosthesis

The precise mechanical properties of many tissues are highly dependent on both the composition and arrangement nanofibrous extracellular matrix. It is well established that collagen nanofibers exhibit a crimped microstructure in several such as blood vessel, tendon, heart valve. This fiber results classic non-linear ‘J-shaped’ stress strain curve characteristic these tissues. Synthetic biomimetic fibrous materials with similar to natural demonstrate following work describes nanofabrication method based electrospinning used fabricate two component hybrid electrospun mimic vascular tissue. samples can be precisely predictably optimized by modifying fabrication parameters. Tubular grafts were constructed potential this graft replacement applications. was possible closely match overall geometry compliance specific vessels optimizing microstructure.