Qfae-Nb Alleviates Pulmonary Fibrosis by Inhibiting the Sting Pathway in Mice

• DOI: 10.2139/ssrn.4570638
• Publication Date: 2023-09-18T18:44:23Z
• Authors: Xueping Wei; Junsong Jing; Rongrong Huang; Ting Zhou; Lianhao Wu; Guoteng Ou; Youping Wu; Jingjin Hu; Wenwen Zhu; Yueguo Wu; Yuanyuan Li; Sheng Zhang; Zhenqiang You
• Keywords: Sting

Ethnopharmacological revelvance: Pulmonary fibrosis (PF) is an irreversible lung disease that severely affects human respiratory function. Traditionally, the natural plant Quzhou Fructus Arantii (QFA) has therapeutic effects on diseases. However, and mechanism of anti-pulmonary have not been elucidated.Aim study: In this study, QFAE-nB was extracted from QFA, objectives study include understanding correlation between Bleomycin (BLM)-induced PF STING pathway in mice, as well exploring role mechanisms treatment PF.Materials Methods: using extraction method, main chemical components were identified. qPCR western blot used to verify molecular QFAE-nB, anti-fibrotic effect determined by hematoxylin-eosin (HE) staining Masson immunohistochemistry. TREX1-KO STING-KO mice relationship important targets action QFAE-nB.Results: The results showed BLM-induced associated with its exacerbated release proinflammatory factors chemokines tissues. addition, alleviated inhibiting activation stimulator interferon genes (STING) signaling reducing TBK1–IRF3 TBK1–NF-κB pathways. Notably, overactivated caused massive inflammation even induced tissues, whereas effectively reduced PF. deletion gene suppressed inflammation, but treated lower expression levels chemokine.Conclusions: We hypothesized plays alleviates targeting inhibition pathway.