Gold Nanoparticle-Mediated Photothermal Therapy Guidance with Multi-Wavelength Photomagnetic Imaging

• DOI: 10.2139/ssrn.4577149
• Publication Date: 2023-09-26T17:31:20Z
• Authors: Farouk Nouizi; Maha Algarawi; Hakan Erkol; Gultekin Gulsen
• Keywords: magnetic resonance thermometry; Medicine (General); photothermal therapy; Photothermal Therapy; Medical Biotechnology; Oncology and Carcinogenesis; Biophysics; 610; Metal Nanoparticles; Bioengineering; Article; Photo-magnetic imaging; R5-920; photothermal agents; Neoplasms; Nanotechnology; Humans; multi-wavelength imaging; Gold nanoparticles; Cancer; Photosensitizing Agents; Biomedical and Clinical Sciences; Photothermal agents; Oncology and carcinogenesis; 540; Photothermal therapy; Multi-wavelength imaging; Photochemotherapy; gold nanoparticles; Gold; Magnetic resonance thermometry

Difficulty in heating tumors with high spatial selectivity while protecting surrounding healthy tissues from thermal harm is a challenge for photothermal treatment (PTT) of cancer. To mitigate this problem, PTT mediated by agents (PTAs) has been established as potential therapeutic technique to boost and reduce damage tissues. A variety gold nanoparticles (AuNP) effectively utilized PTAs, particularly using strategies target cancerous tissue increase the selective damage. Meanwhile, imaging can be used tandem monitor AuNP distribution guide PTT. Mainly, parameters impacting induced temperature determined simulation tools, prior effective However, accurate simulations only performed if amount AuNPs accumulated tumor known. In study, we introduce Photo-Magnetic Imaging (PMI), which recover concentration appropriately Using multi-wavelength measurements, PMI provide based on their distinct absorption spectra. Tissue-simulating phantom studies are conducted demonstrate recovering planning. The recovered accurately model small inclusion representing multiphysics solver that takes into account light propagation heat diffusion turbid media