L-Arginine Regulates Immune Functions in Chickens Immunized with Intermediate Strain of Infectious Bursal Disease Vaccine

• DOI: 10.2141/jpsa.0140101
• Publication Date: 2014-09-24T19:50:45Z
• Authors: Jianzhuang Tan; Yuming Guo; Todd. J. Applegate; Encun Du; Xu Zhao
• Keywords: Infectious bursal disease; Newcastle Disease

The present study investigated the effects of dietary arginine (Arg) supplementation on immune functions broiler chickens inoculated with infectious bursal disease vaccine (IBDV). A total 500 one-day-old female Ross (308) broilers were randomly assigned into 10 treatments (5 replicates per treatment, birds replicate). On day 14, intramuscularly IBDV or saline. Birds fed diets containing one five Arg concentrations: 9.9, 13.9, 17.6, 21.3, 25.3 g/kg respectively. inoculation significantly reduced (P<0.05) serum lysozyme and IgA concentration, mitogen-stimulated peripheral blood mononuclear cell (PBMC) proliferation (Con A), PBMC in vitro NO H2O2 yield, anti-Newcastle virus (NDV) body titers. Increasing concentration linearly increased quadratically (LPS). Serum anti-IBDV antibody titers tended to be (P＝0.06) by increasing concentration. requirement (18.9±0.5) for minimum FCR was higher than that un-inoculated (16.0±1.3). requirements highest (17.5±0.6 g/kg) (LPS) (19.8±2.1 (P<0.10) those (IgA: 16.1±0.6 g/kg; (LPS): 16.3±0.8 g/kg). These results indicate may have a potential effect alleviating IBDV-inoculation induced immunosuppression via enhancing function chickens.