Voriconazole concentration monitoring at an academic medical center

• DOI: 10.2146/ajhp150372
• Publication Date: 2016-02-19T11:15:20Z
• Authors: Jamielynn C. Sebaaly; Shawn H. MacVane; Tanna B. Hassig
• Keywords: Dose

Results of a study the relationship among voriconazole dosages, serum concentrations, adverse effects, and clinical outcomes are presented.A retrospective chart review was conducted that included all patients who had at least one concentration drawn between July 1, 2009, August 15, 2014, single academic medical center. The primary outcome proportion with initial concentrations in target range.Forty-seven 88 (53%) an within range, 27% (24 88) above 19% (17 below range. Sixty-seven percent above-target effects. Voriconazole discontinued 9% patients, dosages were reduced 11% because for treatment versus prophylaxis analyzed subgroup, as obesity nonobesity. Twenty-four died during their hospital admission, 14% not discharged on therapy. within-target group highest lowest deaths.A institution revealed first measured range 53% dosage modified only 51% whose outside majority effect, this result particularly common body mass index ≥35 kg/m(2).