A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

• DOI: 10.2147/ceg.s42260
• Publication Date: 2013-04-18T04:46:58Z
• Authors: Rejane Mattar; Marques; Santos; Monteiro; Iriya; Carrilho
• Keywords: Rapid urease test

Objective: To verify whether the variable number of tandem repeat (VNTR) polymorphism in IL-1RN gene that encodes interleukin (IL)-1 receptor antagonist (IL-1Ra) plays a role outcome gastrointestinal diseases associated with Helicobacter pylori ( H. ) infection. Methods: Patients normal endoscopy (n = 71), inflammation upper tract only 196), gastric ulcer 28), duodenal 76), and cancer 19) were studied. infection was diagnosed by urease test, histological examination, polymerase chain reaction. The IL-1 intron 2 VNTR) analyzed Gastritis scored according to updated Sydney system classification. Results: an independent risk factor for mild (odds ratio [OR] 5.53 [95% confidence interval [CI] 2.63–11.64; P < 0.05]), moderate (OR 83.93 CI 29.7–237.18; 0.05]) marked 47.47 5.39–418.05; gastritis. carriage *2/*2 had significant protective effect 0.31 0.17–0.57; 0.05]). identified as inflammation, ulcer, ulcer. 5.81 1.06–31.98; 0.05]); nonetheless, allele plus *L/*2) on 0.45 0.22–0.91; Conclusions: Allele VNTR against infection; however, it increased cancer. Keywords: , polymorphism, cancer, peptic