<p>Osmotic stress and mortality in elderly patients with kidney failure: a retrospective study</p>

• DOI: 10.2147/cia.s158987
• Publication Date: 2019-01-29T17:33:08Z
• Authors: Caroline GRANGEON...; Manuela DODOI; Vincent ESNAULT; Guillaume FAVRE
• Keywords: Hypernatremia; Azotemia; Nephrology; Univariate analysis

Water balance disorders are associated with a high risk of death in elderly patients. The role osmotic stress intensity and its direction toward hypo- or hypernatremia is matter controversy regarding patients' survival. aims this study were, first, to measure the frequency cellular hydration patients over 75 years old hospitalized nephrology department for reversible acute renal failure, second, compare impact hyperhydration hypohydration on at 6 months.We retrospectively studied data 279 chronic kidney disease (CKD), aged older, pre-renal azotemia who experienced dysnatremia. We classified them according natremia levels compared their outcome univariate multivariate analysis.The were average 83.2±5.4 old. Among them, 128 normonatremic, 82 hyponatremic 69 hypernatremic. Osmotic appreciated by variation rate did not differ significantly between hyper- Patients had CKD stage 3B 4 injury (AKI) different severities. observed that only was linked first months following hospital discharge.Hypernatremia strong predictor fatal suffering from impairment referred azotemia.