The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers

• DOI: 10.2147/cia.s160756
• Publication Date: 2018-09-03T18:37:21Z
• Authors: Cay Anderson-Hanley; Jessica Stark; Kathryn M Wall; Marisa VanBrakle; Makenzie Michel; Molly Maloney; Nicole Barcelos; Kristina Striegnitz; Brian Cohen; Arthur F Kramer
• Keywords: Cognitive Decline; Pilot trial; Cognitive skill; Neuropsychological Assessment

Alzheimer's and related dementias are on the rise, older adults their families seeking accessible effective ways to stave off or ameliorate mild cognitive impairment (MCI).This pilot clinical trial (ClinicalTrials.gov Identifier: 03069391) examined neuropsychological neurobiological outcomes of interactive physical mental exercise.Older (MCI caregivers) were enrolled in a 3-month, in-home portable neuro-exergame (the Physical Cognitive Exercise System [iPACES™]), which they pedaled steered along virtual bike path complete list errands (Memory Lane™). Neuropsychological function salivary biomarkers measured at pre-, mid-, posttrial. Ten complied with recommended use iPACES (complete dose; ≥2×/wk, 67% 15 who also had pre- postevaluation data). Statistical analyses compared change over time among those dose vs inadequate dose. Correlations between biomarker measures examined.Executive verbal memory increased after 3 months (p = 0.01; no significant was found an dose). Change moderately associated increasing cognition (cortisol, r 0.68; IGF-1, 0.37).Further research is needed, but these data provide preliminary indications suggest neuro-exergaming can impact function, perhaps via mechanisms, as such may practical way promote healthy aging.