Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer’s disease

• DOI: 10.2147/cia.s40405
• Publication Date: 2013-01-30T18:04:04Z
• Authors: Xiao-Hong Li; Xiao-Hong Li; Yuan-Yuan Zhang; Min Wang; Dong Wang
• Keywords: Amyloid beta; Proinflammatory cytokine

Background and aim: Amyloid-beta (Aβ) peptide is reported to initiate flexible inflammation in the hippocampus of human brain Alzheimer's disease (AD). The present study aimed investigate possible effects atorvastatin on production cytokines potential impacts behavioral ability, an AD model. Methods: We firstly established rat models using intracerebroventricular injection Aβ1-42. A Morris water maze was also performed determine spatial learning memory ability models. Intracellular staining interleukin (IL)-1β, IL-6, tumor necrosis factor alpha determined immunohistochemical at 6 hours day 7 after Aβ. Results: escape latency atorvastatin-treated group (5 mg/kg/d) significantly shorter than that 3 (41 ± 1.05 seconds versus 47 seconds, P < 0.01) 4 (34 1.25 43 1.01 beginning training. Furthermore, displayed a significant higher mean number annulus crossings did (2.9 0.5 2.4 0.9, 0.05). Fewer injured nerve cells proliferated glial were demonstrated group. Of great importance, we IL-1β, decreased Conclusion: Atorvastatin might attenuate damage improve by inhibiting inflammatory response progression AD. Keywords: amyloid-beta, inflammation, interleukin-1β, interleukin-6,