Efficacy of micronutrient supplementation on skin aging and seasonal variation: a randomized, placebo-controlled, double-blind study

• DOI: 10.2147/cia.s43976
• Publication Date: 2013-11-14T03:32:52Z
• Authors: Ferial Fanian; Jeudy; Lihoreau; Rafat Messikh; Jean-Paul Ortonne; Ahmed Elkhyat; Alexandre Guichard; Hejazi Kenari; Philippe Humbert; Mac-Mary; Sainthillier
• Keywords: Adult; winter variation; skin elasticity; Visioscan®; 03 medical and health sciences; 0302 clinical medicine; Double-Blind Method; Confidence Intervals; Humans; Micronutrients; Original Research; Skin; Ultrasonography; nutraceuticals; seasonal variation; skin relief; high frequency ultrasound; RC952-954.6; Middle Aged; Skin Aging; 3. Good health; Treatment Outcome; Geriatrics; Clinical Interventions in Aging; Dietary Supplements; Reviscometer®; Female; Seasons; oral supplementation

Background: Several studies have confirmed dramatic changes in skin surface parameters during the winter months. Although there are many supporting positive effects of topical treatment, no published demonstrating oral supplementation prevention negative winter. The purpose this study was to evaluate efficacy an micronutrient supplement preventing weather on quality using noninvasive biometrologic instruments. Methods: This included 80 healthy female volunteers aged 35–55 years with phototype II–IV skin. Randomization balanced. Two tablets a (Perfectil ® Platinum) or placebo were administered once daily for 4 examined at baseline, after months, and 6 weeks termination treatment (month 5.5). evaluation microrelief by Visioscan as main outcome, secondary outcomes results standard macrophotography, tension Reviscometer , high-frequency ultrasound, self-assessment. Results: For all pseudoroughness indicators, significant increase from baseline month group ( P <0.05) but change active group. Descriptive statistics mean minimum, maximum, minimum maximum ratio nonexposed zone showed difference between 5.5 group, indicating decreasing anisotropy High-frequency ultrasound exposed revealed that thickness significantly decreased stable treated <0.01). photography scaling self-assessment questionnaire either Conclusion: These indicate is prone seasonal winter, particularly areas. data also can be safe serious side effects, may prevent even eliminate Keywords: supplementation, skin, elasticity, relief, nutraceuticals, variation