<p>The Association Between Rhabdomyolysis, Acute Kidney Injury, Renal Replacement Therapy, and Mortality</p>

• DOI: 10.2147/clep.s254516
• Publication Date: 2020-09-24T01:50:16Z
• Authors: Finn Erland Nielsen; Johan Joakim Cordtz; Thomas Bøjer Rasm...; Christian Fynbo C...
• Keywords: Renal replacement therapy; Creatine kinase; Interquartile range

We examined the association between creatine phosphokinase level in rhabdomyolysis patients and risk of acute kidney injury, renal replacement therapy, death within 30 days.The cohort included admitted with from November 1, 2011 to March 2014. Rhabdomyolysis was defined as a higher than 1000 U/L. Information on laboratory variables obtained database. Medical data were registries. Acute injury according Kidney Disease Improving Global Outcome (KDIGO) guidelines. The 30-day outcomes estimated using cumulative incidence method. Spline regression applied imputed datasets adjustment for baseline used assess appropriateness categorization chosen (1000-5000 U/L, 5001-15,000 15,000+ U/L).The study 1027 (58.2% male) median age 73.5 years. at diagnosis 2257 U/L (interquartile range=1404-3961 U/L). risks three creatinine levels 42% (95% CI=38-45%), 44% CI=36-52%), 74% CI=57-85%), respectively, therapy 3% CI=2-5%), 4% CI=2-7%), 11% (3-23%), respectively. 17% CI=14-20%), 16% CI=11-22%), CI=3-23%), With increasing levels, spline plots supported well decreasing death. However, estimates imprecise.Elevated initial values associated an increased while imprecise.