Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors

• DOI: 10.2147/clep.s34285
• Publication Date: 2012-11-06T20:24:46Z
• Authors: Aliki Taylor; Primrose; Wendy Langeberg; Kelsh; Fionna Mowat; Dominik Alexander; Michael Choti; Graeme Poston; Gena Kanas
• Keywords: Carcinoembryonic antigen

Background: Hepatic metastases develop in approximately 50% of colorectal cancer (CRC) cases. We performed a review and meta-analysis to evaluate survival after resection CRC liver (CLMs) estimated the summary effect for seven prognostic factors. Methods: Studies published between 1999 2010, indexed on Medline, that reported CLMs, were reviewed. Meta-relative risks by factor calculated, stratified study size annual clinic volume. Cumulative results volume plotted. Results: Five- 10-year ranged from 16% 74% (median 38%) 9% 69% 26%), respectively, based 60 studies. The overall median time was 3.6 (range: 1.7–7.3) years. (95% confidence intervals) were: node positive primary, 1.6 (1.5–1.7); carcinoembryonic antigen level, 1.9 (1.1–3.2); extrahepatic disease, (1.5–2.4); poor tumor grade, (1.3–2.7); margin, 2.0 (1.7–2.5); >1 metastases, (1.4–1.8); >3 cm diameter, 1.5 (1.3–1.8). meta-analyses suggested improved with increasing Conclusion: following CLM All investigated factors showed modest but significant predictive relationship survival, certain may prove useful determining optimal therapeutic options. Due complexity surgical interventions inclusion patients higher disease burdens, future studies should consider potential selection referral bias survival. Keywords: metastatic cancer, resection,