Prognostic value of site-specific metastases and therapeutic roles of surgery for patients with metastatic bladder cancer: a population-based study

• DOI: 10.2147/cmar.s148856
• Publication Date: 2017-11-15T02:57:13Z
• Authors: Fan Dong; Yifan Shen; Fengbin Gao; Tianyuan Xu; Xianjin Wang; Xiaohua Zhang; Shan Zhong; Minguang Zhang; Shanwen Chen; Zhoujun Shen
• Keywords: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Surveillance Epidemiology and End Results; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Cancer Management and Research; metastatic site; bladder cancer; prognosis; metastasectomy; radical cystectomy; RC254-282; Original Research

Background: We aimed to evaluate the prognostic value of site-specific metastases in patients with metastatic bladder cancer and analyze roles that surgeries play treatment this malignancy. Materials methods: A population-based retrospective study using Surveillance, Epidemiology End Results dataset was performed were classified according sites (bone, brain, liver, lung distant lymph nodes). Kaplan–Meier analysis log-rank test used for survival comparisons. Multivariate Cox regression model employed effect on overall (OS) cancer-specific (CSS). Results: total 1862 from 2010 2014 identified. Bone, nodes most common sites. Patients bone, liver involvement had worse OS CSS compared without corresponding metastases. showed independent factors both CSS, while node metastasis not. Moreover, a single site more favorable ( p <0.001) than multisite Among single-site patients, represented best worst prognosis, respectively. radical cystectomy an predictor better multiple sites, RC did not bring benefits. Besides, site, metastasectomy seemed be associated =0.042), especially age <65 years =0.006) muscle-invasive =0.031). Conclusion: Distant have differential impact outcomes cancer. Surgeries, including metastasectomy, might still lead benefits highly selected patients. Keywords: cancer, cystectomy,