Bone metastasis pattern in initial metastatic breast cancer: a population-based study

• DOI: 10.2147/cmar.s155524
• Publication Date: 2018-02-08T17:19:58Z
• Authors: Zhenchong Xiong; Guangzheng Deng; Xinjian Huang; Xing Li; Xinhua Xie; Jin Wang; Zeyu Shuang; Xi Wang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Cancer Management and Research; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; molecular subtype; Initial metastatic breast cancer; bone; survival; RC254-282; Original Research; 3. Good health

Bone metastasis pattern in initial metastatic breast cancer: a population-based study Zhenchong Xiong,1–3,* Guangzheng Deng,1–3,* Xinjian Huang,1–3,* Xing Li,1–3 Xinhua Xie,1–3 Jin Wang,1–3 Zeyu Shuang,1–3 Xi Wang1–3 1Department of Breast Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China; 2State Key Laboratory Oncology Southern China, 3Collaborative Innovation Center for Medicine, China *These authors contributed equally to this work Purpose: is one the most common sites cancer metastasis, and studies patients with bone (MBC) are lacking. Materials methods: From 2010 2013, 245,707 8901 diagnosed were identified by Surveillance, Epidemiology, End Results database National Institute. Multivariate logistic Cox regression used identify predictive factors presence prognosis factors. Kaplan–Meier method log-rank test survival analysis. Results: Eight thousand nine hundred MBC had involvement, accounting 3.6% entire cohort 62.5% MBC. Also, 70.5% hormone receptor (HR) positive (HR+/human epidermal growth factor 2 [HER2]−: 57.6%; HR+/HER2+: 12.9%). Patients better 5-year rate compared those brain, liver, or lung metastasis. HR+/HER2− HR+/HER2+ propensity correlated Local surgery significantly improved overall Conclusion: Our has provided estimates epidemiologic characteristics at time diagnosis. These findings would lend support optimal surveillance treatment cancer. Keywords: cancer, bone, molecular subtype,