Expression of 4E-BP1 and phospho-4E-BP1 correlates with the prognosis of patients with clear cell renal carcinoma

• DOI: 10.2147/cmar.s158547
• Publication Date: 2018-06-14T21:39:01Z
• Authors: Feng Li; Qingshui Wang; Xiaoxue Xiong; Chenyi Wang; Xiaohua Liu; Ziqiang Liao; Ke Li; Bifeng Xie; Yao Lin
• Keywords: EIF4E

Eukaryotic translation initiation factor 4E (eIF4E) is a key regulator of protein synthesis. Changes in eIF4E activity disproportionally affect the subset oncogenic mRNAs some cancers.We have assessed expression levels vascular endothelial growth C (VEGFC), eIF4E, eIF4E-binding proteins (4E-BPs) and phospho-4E-BP1 clear cell renal carcinoma (ccRCC; n=101) using immunohistochemistry analyzed relevant mRNA survival online databases.The VEGFC, an eIF4E-regulated gene, were upregulated ccRCC tissues compared with adjacent normal tissues, indicating enhanced ccRCC. The had no significant changes tissues. However, 4E-BP1 found to be overexpressed (P<0.05), high correlated unfavorable clinical outcome patients. Meanwhile, PIK3CD PIK3CG ccRCC.From these results, we could infer that increase may caused by increased level, which was probably due activation phosphoinositide 3-kinase (PI3K) pathway.