Progression and prognostic value of ECT2 in non-small-cell lung cancer and its correlation with PCNA

• DOI: 10.2147/cmar.s170033
• Publication Date: 2018-09-27T20:03:19Z
• Authors: Xianguang Bai; Ming Yi; Xichao Xia; Shengnan Yu; Xinhua Zheng; Kongming Wu
• Keywords: Tissue microarray; Tumor progression

Purpose: Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor, which involved in division regulation and cycle modulation. Recent evidence indicates that ECT2 overexpressed many human cancers. However, the exact prognostic value of lung cancer has not been elucidated. Patients methods: In current study, we performed correlation prognosis analyses using public databases conducted immunohistochemical staining tissue microarrays, samples from 204 patients with survival data. Results: We found expression was markedly increased tissues compared normal tissues. Moreover, demonstrated related to tumor differentiation degree, TNM stage, lymph node metastasis, non-small-cell (NSCLC). A analysis indicated levels were significantly correlated proliferating nuclear antigen (PCNA) NSCLC. Furthermore, Kaplan–Meier revealed high associated unfavorable overall (OS) progression-free (PFS) NSCLC patients. Conclusion: Taken together, these results indicate overexpression contributes invasion progression, suggesting potential marker for Keywords: epithelial 2, ECT2, non-small cancer, prognosis, antigen, PCNA