Comparison between NOD/SCID mice and BALB/c mice for patient-derived tumor xenografts model of non-small-cell lung cancer

• DOI: 10.2147/cmar.s181272
• Publication Date: 2018-12-05T18:34:12Z
• Authors: Jianbin Wu; Juntao Zhang; Mei Jiang; Tianhui Zhang; Yue Wang; Ziyu Wang; Yaodong Miao; Zitong Wang; Weiying Li
• Keywords: BALB/c; NOD mice; Ratón

Patient-derived tumor xenografts (PDX) are considered as a more reliable experiment model for screening chemotherapeutic drugs. However, the tumorigenic rate differs depending on mouse strains, which generates experimental variability.In this study, we built PDX models of human non-small-cell lung cancer (NSCLC) in NOD/SCID mice comparison with BALB/c mice.The result showed that tumorigenesis (46.2%, 18/39) was higher than (17.39%, 4/23). Latent times (41±18 days) were shorter these (53±17 days). Times (85±25 (104±14 In addition, squamous carcinoma tissues likely to form tumors adenocarcinoma (P=0.008) and (P=0.09). Also could retain patients' characteristics xenograft models.It is worth mentioning drug consistent effect clinical chemotherapy. As result, have advantages tumorigenesis, latent over models. It can provide screening.