<p>Peri-tumor fibroblasts promote tumorigenesis and metastasis of hepatocellular carcinoma via Interleukin6/STAT3 signaling pathway</p>

• DOI: 10.2147/cmar.s192263
• Publication Date: 2019-04-09T17:34:10Z
• Authors: Zhenxiong Zhao; Si Xiong; Ronghua Wang; Yawen Li; Xiju Wang; Yun Wang; Shuya Bai; Wei Chen; Yuchong Zhao; Bin Cheng
• Keywords: Peri

Purpose: Because many hepatocellular carcinoma (HCC) cases develop from fibrotic or cirrhotic livers, fibroblasts are abundant in the microenvironment of HCC. Although contribution cancer-associated (CAFs) to progression HCC is well established, role has not been comprehensively revealed. Patients and methods: The RayBio Human Cytokine Antibody Array was used elucidate peri-tumor (PTFs) promoting malignant properties IL-6 STAT3 signaling were inhibited both cell lines non-tumor L-02 liver cells further determine its Moreover, expression pTyr705 detected samples tissues by immunohistochemical staining. Results: PTFs only promoted proliferation, invasion, metastasis cancer cells, but also stimulated permanent transformation human resulting hepatocarcinogenesis vivo. indicated that secreted a higher level soluble than CAFs. derived greatly activated Tyr705 phosphorylation cells. IL-6-neutralizing antibody inhibitor, cryptotanshinone, largely abolished positive effects on carcinogenesis progression. high significantly correlated with tumor recurrence rate after three years postsurgical follow-up patients Conclusion: These results induce development via signaling. Keywords: PTFs, HCC, carcinogenesis, metastasis,